论文标题 / A high-coverage Neandertal genome from Vindija Cave in Croatia
期刊 / Science
发表时间 / 2017-11-03
数字识别码 / 10.1126/science.aao1887
To date, the only Neandertal genome that has been sequenced to high quality is from an individual found in Southern Siberia. We sequenced the genome of a female Neandertal from ~50,000 years ago from Vindija Cave, Croatia, to ~30-fold genomic coverage. She carried 1.6 differences per 10,000 base pairs between the two copies of her genome, fewer than present-day humans, suggesting that Neandertal populations were of small size. Our analyses indicate that she was more closely related to the Neandertals that mixed with the ancestors of present-day humans living outside of sub-Saharan Africa than the previously sequenced Neandertal from Siberia, allowing 10 to 20% more Neandertal DNA to be identified in present-day humans, including variants involved in low-density lipoprotein cholesterol concentrations, schizophrenia, and other diseases.
（导读 陈月欣） 迄今为止，唯一一份高质量尼安德特人基因组样本来自于南西伯利亚。本研究对约 50,000 年前克罗地亚 Vindija 洞穴的一位女性尼安德特人进行了高质量基因组测序，发现他们的群体应该较小，并推测现代人可能拥有比此前估计更多的尼安德特人基因。