新皮质中功能不同的细胞组成栅栏系统

上传 / 管理员 ·2017-11-12 生物学,细胞生物学,新皮质,微柱

论文标题 / Lattice system of functionally distinct cell types in the neocortex

作者 / Toshihiko Hosoya, Hisato Maruoka, et al.

期刊 / Science

发表时间 / 2017-11-03

数字识别码 / 10.1126/science.aam6125

关注此文
分享至:

【论文摘要】

The mammalian neocortex contains many cell types, but whether they organize into repeated structures has been unclear. We discovered that major cell types in neocortical layer 5 form a lattice structure in many brain areas. Large-scale three-dimensional imaging revealed that distinct types of excitatory and inhibitory neurons form cell type–specific radial clusters termed microcolumns. Thousands of microcolumns, in turn, are patterned into a hexagonal mosaic tessellating diverse regions of the neocortex. Microcolumn neurons demonstrate synchronized in vivo activity and visual responses with similar orientation preference and ocular dominance. In early postnatal development, microcolumns are coupled by cell type–specific gap junctions and later serve as hubs for convergent synaptic inputs. Thus, layer 5 neurons organize into a brainwide modular system, providing a template for cortical processing.

 

科研圈

(导读 严冰)哺乳动物新皮质中不同类型的细胞是否会形成反复的结构模式还未研究清楚。本文报道位于新皮质第五层的不同类型细胞形成细胞类型特异性的放射状聚簇结构——微柱(microcolumn),大量的微柱形成六角形马赛克模式镶嵌在不同新皮质区域。位于同一微柱内的神经元有相似特征的视觉反应。早期产后发育时期,微柱由细胞类型特异性的缝隙链接相连,发育后期称为聚合性突触输入的中心。这为皮质信号处理研究提供模板。

参与评论

提交评论
正在加载 正在加载

身份认证

  • 真实姓名
  • 所在单位
  • 单位邮箱
  • 成果发表
  • ORCID

取消 提交

正在加载